The former Real Madrid playmaker’s extension runs until 2027.
Isco has signed a contract extension with Real Betis until 2027, the club have announced.
The midfield player, who joined Betis from Sevilla in the summer, has scored twice in 17 LaLiga appearances this season.
The former Real Madrid man has been an important player for Manuel Pellegrini’s side, who sit in seventh place ahead of their trip to Celta Vigo next week.